Rekha's Publications, Presentations and Other
   Scientific Achievements

PUBLICATIONS:

• Fourier transform vibrational circular dichroism from 800 to 10,000 cm-1: Near IR-VCD spectral standards for terpenes and related molecules; Changning Guo, Rekha D. Shah, Rina K. Dukor, Teresa B. Freedman, Xiaolin Cao, and Laurence A. Nafie; Vibrational Spectroscopy, 42 (2006) 254-272.
• “Enantiomeric Excess Determination by Fourier Transform Near-IR-VCD Spectroscopy: Simulation of Real-Time Process Monitoring" Changning Guo†, Rekha D. Shah, Rina K. Dukor, Xiaolin Cao, Teresa B. Freedman and Laurence A. Nafie*. Applied Spectroscopy, Volume 59 (9): 1114-24, 2005
• “Extension of Fourier Transform Vibrational Circular Dichroism into the Near-Infrared Region: Continuous Spectral Coverage from 800 to 10 000 cm(-1)”, Xiaolin Cao, Rekha D Shah, Rina K Dukor, Changning Guo, Teresa B Freedman, Laurence A Nafie; Applied Spectroscopy, Volume 58(9):1057-1064, 2004
• “Determination of enantiomeric excess in samples of chiral molecules using Fourier vibrational circular dichroism spectroscopy: Simulation of real-time reaction monitoring” by Changning Guo, Rekha D. Shah, Rina K. Dukor, Xiaolin Cao, Teresa Freedman, Laurence A. Nafie, Anal. Chem, 76, 69566966 (2004)
• “Enantio-selective chromatography using on-line polarimetric detection with carbon dioxide based mobile phases”, Fiona Gieser and Rekha D. Shah, Chirality, 16, 263-266, 2004
• Fast method development and rapid analysis using a screening approach for enantiomeric separations in capillary electrophoresis, M. Ilias Jimidar, Willy Van Ael, Rekha Shah, Dirk Redlich and Maurits De Smet; Journal of capillary electrophoresis and microchip technology, J.Cap.Elec. and Microchip Tech. 008:5/6, 2003
• “Quantitative analysis of incomplete HPLC resolution of enantiomers. Fit of polarimetric detection for D- and L-phenylalanine to a Gaussian function”, Tomas J. Edkins, Peter C. Meier, Rekha D. Shah, Donald R. Bobbitt, Hewva Saranadasa, and Romeo D. Lodevico; Enantiomer, Vol. 7, 11-22, 2002
• "Determination of the absolute configuration of a key tricyclic component of a novel vasopressin receptor antagonist by use of vibrational circular dichroism", Alexey B. Dyatkin, Teresa b. Freedman, Xiaolin cao, Rina K. Dukor, Bruce E. Maryanoff, Cynthia A. Maryanoff, Jay M. Mathews, Rekha D. Shah*, and Laurence A. Nafie; Chirality, 14, 215-219, 2002
• "Spectroscopic methods for determining enantiomeric purity and absolute configuration in chiral pharmaceutical molecules, Rekha D. Shah and Lawrence A. Nafie, Current opinion in drug discovery and development, Current Opinion in Drug Discovery & Development, Vol 4, Page 764-775, 2001
• An improved synthesis of enantiomerically pure RWJ-69442, a development candidate for the treatment of benign prostatic hyperplasia, Gee-hong Kuo*, Catherine Prouty, William V. Murray, and Rekha D. Shah, Journal of Heterocyclic chemistry, 38, 1003, 2001
• "An expedient method for resolution of 3-amino-3-(3'-pyridyl)propionic acid and related compounds", Heinz Boesch, Sergio Cisco-Cancian, Leonard R. Hecker, William J. Hoekstra, Michael Justus, Cynthia A. Maryanoff, Lorraine Scott, Rekha D. Shah, Guenter Solms, Kirk L. Sorgi, Stephen M. Stefanick, Urs Thurnheer, Frank J. Villani, Jr, and Donald G. Walker.; Organic Process Research and Development, Vol 5, Number 1, 23-27, 2001
• Utility of Laser-Based Polarimetric and Circular Dichroism HPLC Detection for Pharmaceutical Applications. Edkins, Thomas J; Meier, Peter; Roseman, Lisa A; Shah, Rekha D. Abstr.Pap. - Am. Chem. Soc. (2001), 2001, 221st ANYL-007
• Comparison of Vibrational CD, Electronic CD, and Optical Rotation for Enantiomeric Purity Determination of Mixtures of Chiral Pharmaceutical Molecules. Nafie, Laurence A; Freedman, Teresa B; Guo, Changing; Dukor, Rina K; Shah, Rekha D. Abstr. Pap.-Am. Chem. Soc. (2001), 221st ANYL-003
• “Reversed phase HPLC” by Rekha D. Shah and Ralph R. Ryall, chapter for “HPLC: Practical and Industrial Applications”, 2nd Edition, Joel Swadesh Ed; Published by CRC press, Inc. 2001, Chapter 4.
• "An efficient stereoselective synthesis of methyl (S)-3-(3-pyridyl)propanoate", Zhong HM, Cohen JH, Abdel-Magid AF, Kenney BD, Maryanoff CA, Shah RD, Villani, Jr. FJ, Zhang F, and Zhang X.. Tetrahedron Lett. 40, (1999), 7721-7725.
• “An Efficient Stereoselective Synthesis of Methyl (S)-3-Amino-3-(3-pyridyl)propanoate”, Zhong HM, Cohen JH, Abdel-Magid AF, Kenney BD, Maryanoff CA, Shah RD, Villani, Jr. FJ, Zhang F, and Zhang X.. Tetrahedron Lett. 40, (1999), 7721-7725.
• Potent, Orally active GPIIb/IIIa antagonists containing a nipecotic acid subunit. Structure-activity stdies leading to he discovery of RWJ-53308. Hoekstra, William J; Maryanoff Bruce E; Damiano Bruce P; Andrade-Gordo, Patricia; Cohen, Judith H; Costamz, Michael J; Haertlein, Barbara J; Hecker, Leonard R; Hulshizer, Becky L; Kauffman, Jack A; Keane, Patricia; McComsey, David F; Mitchell, John A; Scott, Lorraine; Shah, Rekha D; Yabut, Stephen C;; J. Med. Chem. (1999), 42(25), 5254-5265.
• "An Efficient Method for Resolution of 3-Amino-3-(3’-pyridyl)propionic Acid and Related Compounds", S. Cesco-Cancian, J.H. Cohen, L. Hecker, W.J. Hoekstra, C.A. Maryanoff, L. Scott, R.D. Shah, K. L. Sorgi, S. Stefanick, F.J. Villani and D.G. Walker* Org. Process Res. Dev. 1999.
• “A crystallization-induced asymmetric transformation to prepare (R)-4-chlorophenylalanine methyl ester” Cynthia A. Maryanoff, Lorraine Scott, Rekha D. Shah and Frank J. Villani Jr. Tetrahedron: Asymmetry 9 (1998) 3247-3250.
• “Hydrolysis of polypeptide esters with tetrabutylammonium hydroxide” Ahmed F. Abdel-Magid, Judith H. Cohen, Cynthia A. Maryanoff, Rekha D. Shah, Frank J. Villani and Fan Zhang. Tetrahedron Letters, 39 (1998) 3391-3394.
• “Reversed phase HPLC” by Rekha D. Shah and Cynthia A. Maryanoff; invited chapter for “HPLC: Practical and Industrial Applications”, Joel Swadesh Ed; Published by CRC press, Inc., 1997, pp 111-169.
• “Reductive amination of aldehydes and ketones with sodium triacetoxyboronhydride.” Studies on direct and indirect reductive amination procedures, Ahmed F. Abdel-Magid, Kenneth G. Carson, Bruce D. Harris, Cynthia A. Maryanoff, and Rekha D. Shah. J. Org. Chem. 1996, Vol 61, Number 11, 3849-3862.
• “High Performance Liquid Chromatographic Analysis of Diastereomers and Enantiomers of Pyrroloisoquinoline Antidepressants, Rekha D. Shah and Cynthia A. Maryanoff, J. Chromatogr. 1991, 588, 347-350.
• “Ligand Assisted Nucleophilic Additions: Control of Site and Face Attack of Nucleophiles on 4-Oxidones”, M. Solomon, W. Charles, L. Jamison, M. McCormick and D. Liotta, D. Cherry, J.E. Mills, R.D. Shah, J.D. Rodgers and C.A. Maryanoff. J. Am. Chem. Soc. 1988, 110, 3702-3704. Cited as benchmark: Chem Tracts-Organic Chemistry, November/December 1988.
• “Reaction of Substituted N-Methylbenzimidoyl Chlorides with Pyrrolo-2-acetate Esters”, John E. Mills, Robin M. Cosgrove, Rekha D. Shah. J. Org. Chem. 1984, 49, 546-547.
• “Stability Constant and Molar Absorptivities for Complexes of Chromium (III) and Cobalt (II) with Pyridylmethaneamine”, J.R. Siefker and R.D. Shah, Telanta, 1979, 26, 505.
  • “Reversed phase HPLC” by Rekha D. Shah and Ralph R. Ryall, chapter for “HPLC: Practical and Industrial Applications”, 2nd Edition, Joel Swadesh Ed; Published by CRC press, Inc. 2001, Chapter 4.
  • “Reversed phase HPLC” by Rekha D. Shah and Cynthia A. Maryanoff; invited chapter for “HPLC: Practical and Industrial Applications”, Joel Swadesh Ed; Published by CRC press, Inc., 1997, pp 111-169.

  PRESENTATIONS

  • “Importance of chiral detectors in enantiomeric purity determinations” Rekha Shah and Yancey Garner, Innovation summit, J&J-PRD, June 2006
  • “Chemistry: You and your future” Rekha Shah, Penn State University, State College, PA, October 2005
  • “Chiral columns or chiral detectors: A question of importance in HPLC chiral methods development; Drexel University, Philadelphia, PA, 2005.
  • Monitoring epimerization of 2,2-dimethyl-1,3-dioxane-4-methanol using near-infrared vibrational circular Dichroism spectroscopy. C. Guo, R.D. Shah, J. Mills, R.K. dukor, X. Cao, T.B. Freedman, L.A. Nafie. 2004 ACS meeting, August 2004, Philadelphia, PA.
  • Preparative Enantio-selective Chromatographic Isolation of Readily Racemized Enantiomers, Michael Breslav, Rosie Chang, Michael Greco, Yong Guo, Chan Ko, Bruce Maryanoff, Cynthia Maryanoff, Mitul Patel, Rekha Shah, and Yun Qian; 16th International symposium, exhibit and workshops on preparative/process chromatography, ion exchange, adsorption/desorption process & related separation techniques, San Francisco, CA. June 29, 2004
  • Analytical Support in Preparation of Drug Substance: Azaline B; Rekha D. Shah, Third Chromatography forum of Delaware Valley Symposium; an Award Talk, April 2003
  • “Chiral Columns or Chiral Detectors? A Question of Importance in HPLC Chiral Methods Development”; Invited talk; FACSS 2002; Rekha Shah; October 2002.
  • “Applications of Electronic and Vibrational Circular Dichroism Detections in Enantio-selective Methods Development”; Invited talk; Rekha D. Shah, Laurence A. Nafie and Changning Guo; First International conference on Biomedical Spectroscopy; Cardiff, Walse, UK. July 2002.
  • “Analytical Support and Analytical Techniques used in Development of Drug Substances”, Syracuse University, Invited talk, Rekha D. Shah, April 2002.
  • Process Development of Two Potential Antithrombotic Agents; Zhanf Xini, Breslav, Michael, Childers Joseph H, Duda Robert J, Goltra, Steven; Grimm, Jeffrey s; Guan, Kaillin; Hortensteine, John T; Liu, Fuqiang; Maryanoff, Cynthia A; Palmer, David c; Pate, Mitul; Qian, Yun; Shah, Rekha D; Sorgi, Kirk L; Stefanick, Stephen M; Villani, Frank J., Jr; Zhang-Plasket; 222nd ACS National Meeting, Chicago, Il; August 2002
  • “Vibrational Chirality: Absolute Configuration, Conformational Analysis and enantiomeric Excess Monitoring with VCD; L. A. Nafie, R. K. Dukor, R. K. Freedman, and R. D. Shah; International Symposium on Chiral Discrimination 2002; Hamburg, Germany; August 2002
  • "Comparison of Vibrational Circular Dichroism, Electronic Circular Dichroism, and Polarimetry Detection Techniques for Enantiomeric Purity Determination"; Invited talk, 13th International symposium on Chirality Rekha D. Shah and Laurence A. Nafie; July 2001
  • "Enantio-selective Chromatography using on-line Chiroptical Detections: Mobile-phase Optimization, 13th International symposium on Chirality; Rekha D. Shah and Fiona Geiser, July 2001
  • "Advantages of Circular Dichroism Detector for Enantiomeric Purity Methods Development,), Invited talk, The 27th Annual Conference of the Federation of Analytical Chemistry and spectroscopy societies (FACSS), Rekha D. Shah and Ralph R. Ryall, September 2000.
  • "Analytical Challenges in Support of RWJ-348260 Synthesis"; RWJ-PRI Science Day 2000; Rekha D. Shah and Lisa A. Roseman; August 2000
  • "Systematic RP-HPLC Methods Development for Small Pharmaceutical Molecules Using Stationary Phase Screening with Understanding of Analyte Functional Group Interaction." Chromatography Forum of Delaware Valley; Rekha D. Shah and Lisa A. Roseman; June 2000.
  • "Applications of Circular Dichroism and Laser-Based Polarimetric HPLC Detection for In-Process Control of Stereoselective Synthesis"; Invited Speaker; MARM 2000; Rekha D. Shah, Thomas J. Edkins, Lisa A. Roseman, and Donald. R. Bobbitt; March 2000
  • "Process Research and Synthesis of RWJ-348260", L. Scott, M.B. Breslav, R. Chang, J. T. Hortenstine, B. D. Kenney, J. Mills, F. Z. Plasket, L. A. Roseman, R. D. Shah, F. J. Villani, J. Xiang; 2000 PRI Science Day, August 2000.
  • "A comparison of Two Quantitation Modes for Enantio-selective Detector" T. J. Edkin, R. D. Shah, L. A. Roseman, and P. Meier, 2000 PRI Science Day, August 2000.
  • "Applications of Circular Dichroism and Polarimetric Detectors for In-process Control of Stereo selective Synthesis." Invited speaker; 26th annual conference of the federation of analytical chemistry and spectroscopy societies (FACSS), Vancouver, Canada, October 1999.
  • "Systematic RP-HPLC Methods Development for Small Pharmaceutical Molecules using Stationary Phase Screening with Understanding of Analyte Functional Group Interaction." 38th Annual Eastern Analytical Symposium; November 1999.
  • “Applications of Circular Dichroism HPLC Detection for In-process Control of Stereoselective Syntheses” RWJ-PRI, Analytical Science Day 1999; Rekha D. Shah, Thomas Edkins, Lisa Roseman, and Donald Bobbitt; August 1999
  • “Systematic RP-HPLC Methods Development for Small Pharmaceutical Compounds using Stationary Phase Screening with Understanding of Analyte Functional Group Interactions”; RWJ-PRI, Analytical Science Day 1999; Lisa A. Roseman, and Rekha D. Shah; August 1999.
  • "Applications of Circular Dichroism HPLC Detection for In-process Control of Stereoselective Syntheses”; 11th International Symposium on Chiral Discrimination; Rekha D. Shah, Thomas J. Edkins, Lisa A. Roseman, and Donald Bobbitt; July 1999
  • “The Stereo-selective Synthesis of Methyl (S)-3-Amino-3-(3-pyridyl) propanoate.”; Kenney, B. D.; Abdel-Magid, A. F.; Cohen, J. H.; Maryanoff, C. A.; Roseman, L.; Shah, R. D.; Villani Jr., F. J.; Xiang, X. J.; Zhang, F.; Zhang, X.; Zhong, H. M. “Process Development for RWJ-53308. Book of Abstracts 36th National Organic Symposium, University of Wisconsin, Madison, WI, June 13, 1999
  • “An Efficient Method for Resolution of 3-Amino-3-(3’-pyridyl) propionic Acid and Related Materials.” Sesco-Cancian, S.; Cohen, J. H.; Hecker, L.; Hoekstra, W. J.; Maryanoff, C. A.; Scott, L.; Shah, R. D.; Sorgi, K. L.; Stefanick, S. M.; Villani Jr., F. J.; Walker, D. G. Book of Abstracts 36th National Organic Symposium, University of Wisconsin, Madison, WI, June 13, 1999.
  • “Analytical Support in Optimization of Chemical Processes” RWJ-PRI, Analytical Science Day 1999; Rekha D. Shah and Xinzhen; August 1998
  • “Application of Laser-Based Polarimetric Detection for Pharmaceutical Analysis” RWJ-PRI, Analytical Science Day 1997; Rekha D. Shah, Thomas Edkins, and Donald R. Bobbit; October 1997
  • “Application of Laser-Based Polarimetric Detection for Pharmaceutical Analysis” (invited speaker); Chiral conference of Americas; Rekha D. Shah, Thomas Edkins, and Donald R. Bobbit; June 1997
  • “Simultaneous Separation of Regio Isomers and Enantiomers of Boc-nitrophenylalanine using HPLC and CZE”, Rekha D. Shah*, Dave C. Palmer and Kirk L. Sorgi.20th International Symposium on High performance liquid phase separation and related techniques, June 1996.
  • “Tetraalkylammonium Hydroxides: Highly Reactive and Efficient Bases for Hydrolysis of Esters. Ahmed F. Abdel-Magid, Cynthia A. Maryanoff, Rekha D. Shah, Frank J. Villani and Fan Zhang; The 35th National Organic Chemistry Symposium, San Antonio, TX, June 1997, paper W287.
  • “Simultaneous Separation of Regio Isomers and Enantiomers of Boc-nitrophenylalanine using HPLC and CZE”; Invited speaker; 35th Eastern Analytical Symposium & Exposition; Rekha D. Shah, Dave C. Palmer and Kirk L. Sorgi; November 1996
  • "HPLC Resolution of Chiral Phosphonic acid Analogs as Their Ester Derivatives on the Chiralcel OJ column”, M.S. Havemose, R.D. Shah, D.M. Desai and J. Stubbs Sixth International Symposium on Chiral Discrimination, April 1995.
  • "Development of a Process and the Importance of Analytical Support in Process Development”; Invited speaker; The Royal Society of Chemistry, London (North India Section), University of Delhi, India, December 1994.
  • “Non-Derivatization HPLC Resolution of Diastereomer and Enantiomers of Octhydroindole-2-carboxylic Acid"; Third Annual J&J Symposium on Chromatography; Rekha D. Shah, Cynthia A. Maryanoff, Raj D. Mehta, Robin C. Stanzione, and Frank J. Villani, Jr.; May 1994.
  • "The Use of Chromatographic Techniques in Development of a Chemical Process"; First Annual J&J Symposium on Chromatography; Rekha D. Shah and Cynthia A. Maryanoff; May 1993.
  • "Octahydroindole-2-carboxylic acid: HPLC Resolution of Diastereomers and Enantiomers.” R. D. Shah, C. A. Maryanoff, R. J. Mehta, R. C. Stanzione and F.J. Villani; Fourth International Symposium on Chiral Discrimination, September 1993.
  • "Analytical Support of a Process to Prepare N-[(3,4-Dimethoxyphenyl)]-5-methoxy-N-dimethyl-2-(phenyl ethynyl) benzenepropanamine." Rekha D. Shah and Cynthia A. Maryanoff.; Pharmaceutical & Cosmetics Engineering World, October 1991.
  • "Analytical Support of a Process to Prepare N-[(3,4-Dimethoxyphenyl)]-5-methoxy-N-dimethyl-2-(phenyl ethynyl) benzenepropanamine." Rekha D. Shah and Cynthia A. Maryanoff. International Forum of Process Analytical Chemistry, January 1991.
  • "Pyrroloisoquinoline Antidepressants: HPLC Resolution of Diastereomers and Enantiomers " Rekha D. Shah, B. E. Maryanoff, C. A. Maryanoff, D. F. McComsey and K. L. Sorgi; International Conference On Chirality, June 1990.
  • "Pyrroloisoquinoline Antidepressants: HPLC Resolution of Diastereomers and Enantiomers " Rekha D. Shah, B. E. Maryanoff, C. A. Maryanoff, D. F. McComsey and K. L. Sorgi; 28th Eastern Analytical Symposium, September 1989.
  • "Pyrroloisoquinoline Antidepressants: HPLC Resolution of Diastereomers and Enantiomers " Rekha D. Shah, B. E. Maryanoff, C. A. Maryanoff, D. F. McComsey and K. L. Sorgi.Philadelphia Organic Chemists Day, June 1989.
  • "A Convenient Synthesis of Guanidines from Thioureas” R. C. Stanzione, C. A. Maryanoff, J. N. Plampin, J. Childers, B. J. Duffy, J. Spink, R. D. Shah, H. Duong and J.E. Mills; 20th Regional Meeting of Middle Atlantic ACS, Baltimore, MD, Sept., 1986; 29th National Organic Symposium, Newark, DE, June, 1985; Philadelphia Organic Chemists Day, June, 1985:
  • 2000-2008: Short course on chiral chromatography, lab and lecture, Continuing education series short course offered by Chromatography Forum of Delaware Valley (CFDV)
  • 2004: Short course on chiral chromatography, 28th International Symposium and Exhibition on High Performance Liquid Phase Separations and related Techniques, (HPLC 2004), Philadelphia, PA, June 2004
  • 1998-2008: Short course on Gas Chromatography, lab instructor, Continuing education series short course offered by CFDV

  Scientific Activities

  • Session chair, “HPLC detection techniques”, 2004 Eastern Analytical Symposium, November 2004, Somerset, NJ.
  • Chiral Sessions (2); FACSS 2003 symposium, Ft. Lauderdale, FL. Organized and chaired two chiral sessions
  • Organizing committee of International Symposium on Chirality, June 2001, Orlando, FL
  • Session chair: international symposium on Chirality, , June 2001, Orlando, FL
  • Session Chair "Pharmaceutical Analysis in Support of Drug Development." (Organized and chaired a session); 38th Annual Eastern analytical symposium; November 1999
  • Session chair ad symposium organizer of “Johnson & Johnson Chromatography symposium” 1994-2007
  • Session chair and symposium organizer of Delaware Valley chromatography symposium, 2000-2007

BOOK CHAPTERS





Short Courses




SCIENTIFIC GROUPS/ACTIVITIES
2000-2001: President, Chromatography Forum of Delaware Valley (CFDV)
1999-2000: Program Chair, Chromatography Forum of Delaware Valley (CFDV)
1998-1999: Secretary, Chromatography Forum of Delaware Valley (CFDV)
1995-present: Elected executive Committee member Chromatography Forum of Delaware Valley (CFDV)
1982-present: American Chemical Society
1982-present: Philadelphia Organic Chemists Club
1992-present: ohnson & Johnson Chromatography Group/Exc.Comt.member
1983-present:Member, The Chromatography Forum of Delaware Valley (CFDV)